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  • 19 Jan 2017

    Gilbert’s Syndrome

    This common disorder affects up to 7% of the population, with a marked male predominance. It commonly manifests during the teens or 20s as mild unconjugated hyperbilirubinemia, exacerbated by ...

  • 18 Jan 2017

    Chronic Gastrointestinal Hemorrhage

    This condition may manifest as self-limited, recurrent episodes of melena or hematochezia, usually not with the degree of hemodynamic compromise discussed earlier. Patients may also have no overt ...

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  • Gilbert’s Syndrome

    This common disorder affects up to 7% of the population, with a marked male predominance. It commonly manifests during the teens or 20s as mild unconjugated hyperbilirubinemia, exacerbated by fasting, and noted clinically as an incidental laboratory finding. The genetic defect involves a mutation in the promoter region of the transferase gene, and its clinical...

  • This condition may manifest as self-limited, recurrent episodes of melena or hematochezia, usually not with the degree of hemodynamic compromise discussed earlier. Patients may also have no overt evidence of blood loss, but rather may have persistent anemia and stools consistently positive for occult blood. The evaluation of this condition differs from that of acute...

  • Screening tests of hepatobiliary disease may be divided into two categories: (1) tests of biliary obstruction and/or cholestasis and(2) tests of hepatocellular damage, based on the mechanisms responsible for the abnormal test. However, none of the tests is specific either category, and it is the overall pattern and the relative magnitude of abnormalities in these...

  • The most common signs and symptoms of chronic pancreatitis are abdominal pain, weight loss, diabetes, and steatorrhea. Other manifestations include obstructive jaundice secondary to compression of the distal common bile duct as it progresses through the scarred and fibrotic pancreatic head, chronic pseudocysts, pancreatic ascites, and gastrointestinal bleeding. Gastrointestinal bleeding is usually secondary to gastric...

  • The treatment of acute pancreatitis is supportive, with intravenous fluids, intake of nothing by mouth, relief of in pain with analgesics, nutritional support, and close clinical observation. In general, the mortality rate of acute pancreatitis is approximately 10%. An estimated 90% of patients recover within the first 2 weeks. Prognosis can be determined at the...